OTX 015

Drug Profile

OTX 015

Alternative Names: MK 8628; OTX-015; Y-803

Latest Information Update: 25 Mar 2017

Price : $50

At a glance

  • Originator Mitsubishi Pharma Corporation
  • Developer Merck & Co; Mitsubishi Tanabe Pharma Corporation; OncoEthix
  • Class 3-ring heterocyclic compounds; Antineoplastics; Azepines; Small molecules; Triazoles
  • Mechanism of Action BRD2-protein-inhibitors; BRD3 protein inhibitors; BRD4-protein-inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Solid tumours
  • Phase I/II Glioblastoma
  • Phase I Haematological malignancies
  • Discontinued Crohn's disease; Ulcerative colitis

Most Recent Events

  • 28 Dec 2016 OTX 015 is still in phase I trials for Haematological malignancies in France, Italy and Switzerland
  • 03 Dec 2016 Pharmacodynamics data from preclinical studies in Haematological malignancies presented at 58th Annual Meeting and Exposition of the American Society of Hematology
  • 29 Nov 2016 Efficacy, pharmacokinetics and adverse events data from a phase Ib trial in Solid tumours data presented at 28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
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