Drug Profile


Alternative Names: APO866; FK 866; NMPRTs

Latest Information Update: 31 Jul 2015

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At a glance

  • Originator Astellas Pharma GmbH
  • Developer TopoTarget Switzerland
  • Class Acrylamides; Antineoplastics; Piperidines; Small molecules
  • Mechanism of Action Angiogenesis inhibitors; Nicotinamide phosphoribosyltransferase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • No development reported Chronic lymphocytic leukaemia; Cutaneous T cell lymphoma; Malignant melanoma

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 27 Jul 2015 No recent reports of development identified - Phase-II for Cutaneous T-cell lymphoma in the European Union and Switzerland (IV)
  • 02 Jun 2015 TopoTarget terminates a phase-II trial in Cutaneous T-cell lymphoma in European Union and Switzerland due to lack of efficacy (NCT00431912)
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