Bardoxolone methyl

Drug Profile

Bardoxolone methyl

Alternative Names: Bard - Reata Pharmaceuticals; CDDO-Me; NSC-713200; RTA-402

Latest Information Update: 18 Nov 2016

Price : $50

At a glance

  • Originator Dartmouth College; University of Texas M. D. Anderson Cancer Center
  • Developer Kyowa Hakko Kirin; Reata Pharmaceuticals; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Small molecules; Triterpenes
  • Mechanism of Action Cyclo-oxygenase 2 inhibitors; I-kappa B kinase inhibitors; NF E2 related factor 2 stimulants; NF-kappa B inhibitors; Nitric oxide synthase type II inhibitors; STAT3 transcription factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pulmonary arterial hypertension; Pancreatic cancer
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Pulmonary arterial hypertension
  • Phase II Diabetic nephropathies
  • Discontinued Haematological malignancies; Malignant melanoma; Non-alcoholic steatohepatitis; Pancreatic cancer; Solid tumours; Viral hepatitis

Most Recent Events

  • 14 Nov 2016 Reata plans a phase II/III trial for Hereditary nephritis (Alport syndrome) in USA
  • 06 Oct 2016 Updated efficacy data from phase II LARIAT trial in Pulmonary arterial hypertension released by Reata Pharmaceuticals
  • 01 Sep 2016 Phase-III clinical trials in Pulmonary arterial hypertension in USA, Czech Republic, Germany, Japan, Spain (PO) (NCT02657356)
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