Bardoxolone methyl

Drug Profile

Bardoxolone methyl

Alternative Names: Bard - Reata Pharmaceuticals; CDDO-Me; NSC-713200; RTA-402

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Dartmouth College; University of Texas M. D. Anderson Cancer Center
  • Developer Kyowa Hakko Kirin; Reata Pharmaceuticals; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Small molecules; Triterpenes
  • Mechanism of Action Cyclo-oxygenase 2 inhibitors; I-kappa B kinase inhibitors; NF E2 related factor 2 stimulants; NF-kappa B inhibitors; Nitric oxide synthase type II inhibitors; STAT3 transcription factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hereditary nephritis; Pancreatic cancer; Pulmonary arterial hypertension
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Hereditary nephritis; Pulmonary arterial hypertension; Pulmonary hypertension
  • Phase II Diabetic nephropathies
  • Discontinued Haematological malignancies; Malignant melanoma; Non-alcoholic steatohepatitis; Pancreatic cancer; Solid tumours; Viral hepatitis

Most Recent Events

  • 30 Aug 2017 Reata Pharmaceuticals plans a phase I trial in Healthy volunteers(NCT03264079)
  • 24 Jul 2017 Phase-III clinical trials in Hereditary nephritis in USA (PO)
  • 24 Jul 2017 Adverse event and efficacy data from the phase II portion of the phase II/III CARDINAL trial in Hereditary nephritis released by Reata Pharmaceuticals
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