Regorafenib

Drug Profile

Regorafenib

Alternative Names: BAY-734506; DAST inhibitor - Bayer; fluoro-sorafenib; Stivarga

Latest Information Update: 04 Nov 2017

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At a glance

  • Originator Bayer HealthCare
  • Developer Bayer HealthCare; British Columbia Cancer Agency; Memorial Sloan-Kettering Cancer Center; Spanish Cooperative Group for Digestive Tumour Therapy
  • Class Amides; Antineoplastics; Fluorobenzenes; Phenylurea compounds; Pyridines; Small molecules
  • Mechanism of Action Platelet-derived growth factor receptor antagonists; Proto oncogene protein b raf inhibitors; Proto oncogene protein c ret inhibitors; Proto oncogene protein c-kit inhibitors; TIE 2 receptor antagonists; Type 1 fibroblast growth factor receptor antagonists; Type 1 fibroblast growth factor receptor modulators; Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hepatocellular carcinoma; Gastrointestinal stromal tumours
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Colorectal cancer; Gastrointestinal stromal tumours; Hepatocellular carcinoma
  • Phase II Adenocarcinoma; Pancreatic cancer; Renal cell carcinoma; Solid tumours
  • No development reported Non-small cell lung cancer
  • Discontinued Wet age-related macular degeneration

Most Recent Events

  • 04 Nov 2017 No recent reports of development identified for phase-I development in Colorectal-cancer in Germany (PO, Tablet)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Non-small-cell-lung-cancer(Combination therapy) in USA (PO, Tablet)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Solid-tumours in Japan (PO, Tablet)
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