Drug Profile


Alternative Names: 1120212; GSK-1120212; GSK-1120212B; JTP-74057; Mekinist; TMT 212

Latest Information Update: 28 Dec 2016

Price : $50

At a glance

  • Originator Japan Tobacco
  • Developer Dana-Farber Cancer Institute; GlaxoSmithKline; Japan Tobacco; National Cancer Institute (USA); Novartis; Pfizer; University of Texas M. D. Anderson Cancer Center
  • Class 2 ring heterocyclic compounds; Amides; Antineoplastics; Cyclopropanes; Fluorobenzenes; Iodobenzenes; Pyridines; Pyrimidines; Small molecules
  • Mechanism of Action MAP kinase kinase 1 inhibitors; MAP kinase kinase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant melanoma
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Malignant melanoma
  • Phase II Acute myeloid leukaemia; Biliary cancer; Brain metastases; Breast cancer; Cancer; Cervical cancer; Endometrial cancer; Multiple myeloma; Non-small cell lung cancer; Pancreatic cancer; Uveal melanoma
  • Phase I/II Colorectal cancer; Solid tumours
  • Phase I Lymphoma; Mesothelioma
  • No development reported Leukaemia
  • Discontinued Inflammation

Most Recent Events

  • 23 Dec 2016 Novartis and Ligand Pharmaceuticals enter into global license and supply agreements for the development and commercialisation of oral liquid formulation of trametinib
  • 22 Dec 2016 Preclinical trials in Malignant melanoma in USA (PO)
  • 18 Oct 2016 GlaxoSmithKline plans a phase I trial for Solid tumours (Late-stage disease, Metastatic disease, Second-line therapy or greater) in China (PO, Tablet) (NCT02939846)
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