Research programme: dioxygenase inhibitors - NewLink Genetics

Drug Profile

Research programme: dioxygenase inhibitors - NewLink Genetics

Alternative Names: Ethyl pyruvate - NewLink Genetics; Indoleamine-2,3-dioxygenase (IDO) pathway inhibitors - NewLink Genetics; Tryptophan-2,3-dioxygenase inhibitors - NewLink Genetics

Latest Information Update: 22 Oct 2014

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At a glance

  • Originator Lankenau Institute for Medical Research
  • Developer Genentech; Lankenau Institute for Medical Research; NewLink Genetics Corporation
  • Class Small molecules
  • Mechanism of Action Indoleamine-pyrrole 2,3-dioxygenase inhibitors; Tryptophan oxygenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Cancer
  • Discontinued Hepatitis C; HIV infections

Most Recent Events

  • 20 Oct 2014 NewLink Genetics enters into a research collaboration with Genentech for the discovery of IDO/TDO compounds
  • 18 Dec 2013 This programme is still active
  • 24 Sep 2012 Preclinical development is ongoing for Cancer in USA
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