Ofranergene obadenovec

Drug Profile

Ofranergene obadenovec

Alternative Names: GT-111; VB 111

Latest Information Update: 10 Jul 2017

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At a glance

  • Originator Vascular Biogenics
  • Developer Dana-Farber Cancer Institute; Massachusetts General Hospital; VBL Therapeutics
  • Class Antineoplastics; Gene therapies
  • Mechanism of Action Angiogenesis modulating agents; Gene expression modulators; Vascular disrupting agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma
  • New Molecular Entity No

Highest Development Phases

  • Phase III Glioblastoma
  • Phase II Ovarian cancer; Thyroid cancer
  • Preclinical Lung cancer; Malignant melanoma

Most Recent Events

  • 14 Aug 2017 VBL Therapeutics plans an exploratory trial for Lung cancer (In combination with a checkpoint inhibitor) in the first quarter of 2018
  • 19 Jun 2017 Efficacy data from a phase II trial in Thyroid cancer released by VBL Therapeutics
  • 19 Jun 2017 Updated efficacy data from a phase II trial in Ovarian cancer released by VBL Therapeutics
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