Drug Profile


Alternative Names: MILR1444A; MILR1444Ab; RG-3637; RO-5490255; TNX-650

Latest Information Update: 15 Jun 2017

Price : $50

At a glance

  • Originator Tanox
  • Developer Chugai Pharmaceutical; Comprehensive Clinical Research Network; Genentech; Roche; Tanox
  • Class Anti-inflammatories; Antiasthmatics; Monoclonal antibodies
  • Mechanism of Action Interleukin 13 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Atopic dermatitis; Idiopathic pulmonary fibrosis
  • Discontinued Asthma; Chronic obstructive pulmonary disease; Hodgkin's disease

Most Recent Events

  • 27 Apr 2017 Discontinued - Phase-II for Chronic obstructive pulmonary disease (Adjunctive treatment) in USA, Bulgaria, Canada, Denmark, Hungary, Poland, Russia, Argentina, Argentina, Mexico (SC) because it did not meet the primary endpoint of a phase II trial (Roche pipeline, April 2017)
  • 16 Mar 2017 Discontinued - Phase-III for Asthma (Adjunctive treatment, In adolescents) in USA, Germany, Portugal, Hungary, Italy, Czech Republic, Spain, Poland, Argentina, Canada, Colombia, France, South Korea, South Korea, Israel, Mexico, Peru, Slovakia, South Africa, Taiwan, Brazil, Japan, Ukraine, United Kingdom (SC) (Roche email communication, March 2017)
  • 01 Feb 2017 Roche completes a phase II trial in Chronic obstructive pulmonary disease (Adjunctive treatment) in USA, Argentina, Bulgaria, Canada, Denmark, Hungary, Mexico, Poland and Russia (NCT02546700)
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