Drug Profile


Alternative Names: MILR1444A; MILR1444Ab; RG-3637; RO-5490255; TNX-650

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Tanox
  • Developer Chugai Pharmaceutical; Comprehensive Clinical Research Network; Genentech; Roche; Tanox
  • Class Anti-inflammatories; Antiasthmatics; Monoclonal antibodies
  • Mechanism of Action Interleukin 13 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Atopic dermatitis; Chronic obstructive pulmonary disease; Idiopathic pulmonary fibrosis
  • Discontinued Asthma; Hodgkin's disease

Most Recent Events

  • 16 Mar 2017 Discontinued - Phase-III for Asthma (Adjunctive treatment, In adolescents) in USA, Germany, Portugal, Hungary, Italy, Czech Republic, Spain, Poland, Argentina, Canada, Colombia, France, South Korea, South Korea, Israel, Mexico, Peru, Slovakia, South Africa, Taiwan, Brazil, Japan, Ukraine, United Kingdom (SC) (Roche email communication, March 2017)
  • 01 Feb 2017 Roche completes a phase II trial in Chronic obstructive pulmonary disease (Adjunctive treatment) in USA, Argentina, Bulgaria, Canada, Denmark, Hungary, Mexico, Poland and Russia (NCT02546700)
  • 12 Jan 2017 Roche terminates the phase II VOCALS trial in Asthma due to absence of efficacy in the LAVOLTA studies in United Kingdom, Canada, France, Netherlands, Puerto Rico, Slovakia, Spain, the US, Belgium, Mexico, Australia, Czech Republic, Denmark, New Zealand, Poland, Bulgaria and Slovenia (SC) (NCT01987492)
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