Drug Profile


Alternative Names: MK-0822; MK-822

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Celera Group
  • Developer Banyu; Merck & Co
  • Class Amides; Biphenyl compounds; Cyclopropanes; Nitriles; Osteoporosis therapies; Small molecules; Sulfones
  • Mechanism of Action Bone resorption factor inhibitors; Cathepsin K inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Bone metastases; Corticosteroid-induced osteoporosis; Male osteoporosis; Osteoarthritis; Osteoporosis; Postmenopausal osteoporosis

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 26 Sep 2016 Merck Sharp & Dohme terminates a phase I trial in Corticosteroid-induced osteoporosis (In adolescents, Prevention, In adults) in USA, United Kingdom, Italy and Finland (NCT01630616, EudraCT2012-003414-14)
  • 16 Sep 2016 Efficacy and adverse events data from an extension study of the phase III LOFT trial in Osteoporosis presented at the 38th Annual Meeting of the American Society for Bone and Mineral Research
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