Glembatumumab vedotin

Drug Profile

Glembatumumab vedotin

Alternative Names: CDX-011; CR 011 ADC; CR 011-vcMMAE; CR011; Glemba; Glembatumumab; GV

Latest Information Update: 07 Dec 2016

Price : $50

At a glance

  • Originator CuraGen Corporation
  • Developer Celldex Therapeutics Inc; National Cancer Institute (USA)
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    Breast cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Breast cancer; Malignant melanoma; Osteosarcoma; Uveal melanoma
  • Phase I/II Squamous cell cancer
  • Discontinued Brain cancer

Most Recent Events

  • 06 Dec 2016 Discontinued - Preclinical for Brain cancer in USA (IV) before November 2016 (Celldex pipeline, November 2016)
  • 09 Oct 2016 Efficacy data from a phase II trial in Malignant melanoma presented at the 41st European Society for Medical Oncology Congress (ESMO-2016)
  • 08 Aug 2016 Phase-II clinical trials in Malignant melanoma (Inoperable/Unresectable, Late-stage disease, Combination therapy) in USA (IV) (NCT02302339),
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