Drug Profile


Alternative Names: L-1178953; MK-0594; VPD-737

Latest Information Update: 22 Sep 2017

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At a glance

  • Originator Merck & Co
  • Developer Epidermolysis Bullosa Research Partnership; Menlo Therapeutics; Merck & Co; Stanford University; Velocity Pharmaceutical Development
  • Class Antipruritics; Cyclopentanes; Isoindoles; Skin disorder therapies; Small molecules; Urologics
  • Mechanism of Action Neurokinin 1 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Prurigo nodularis; Pruritus
  • Discontinued Alcoholism; Overactive bladder

Most Recent Events

  • 22 Sep 2017 Menlo Therapeutics plans a phase II trial for Cough (NCT03282591)
  • 18 Sep 2017 Efficacy, adverse events and post-hoc analysis data from a phase II trial in Pruritus released by Menlo Therapeutics
  • 08 Mar 2017 Efficacy and adverse events data from a phase II trial in Prurigo nodularis released by Menlo Therapeutics
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