Drug Profile


Alternative Names: ACT-128800; Compound 8bo - Actelion; R-3477; RG 3477

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Actelion Pharmaceuticals
  • Class Antipsoriatics; Chlorobenzenes; Imines; Phenyl ethers; Small molecules; Thiazolidines
  • Mechanism of Action Immunomodulators; Sphingosine 1 phosphate receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Multiple sclerosis
  • Phase II Graft-versus-host disease
  • Phase I Immunological disorders
  • No development reported Plaque psoriasis

Most Recent Events

  • 13 Jul 2017 Actelion initiates enrolment in the OPTIMUM-LT phase III trial for Multiple sclerosis in USA (NCT03232073)
  • 16 Jun 2017 Actelion Pharmaceuticals has been acquired by Janssen Pharmaceuticals
  • 05 Apr 2017 Actelion terminates a phase II trial in Graft-versus-host disease in USA due to low recruitment (NCT02461134)
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