Drug Profile


Alternative Names: 18F1; IMC-18F1; LY 3012212; Monoclonal-antibody-18F1

Latest Information Update: 10 Oct 2017

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At a glance

  • Originator ImClone Systems
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Angiogenesis inhibitors; Vascular endothelial growth factor receptor-1 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Breast cancer
  • Discontinued Colorectal cancer; Urogenital cancer

Most Recent Events

  • 01 Jul 2017 Eli Lilly completes a phase II trial in Breast cancer (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second line therapy or greater) in the USA and Canada (NCT01234402)
  • 03 Aug 2015 Phase-II development for Breast cancer is ongoing in USA and Canada
  • 01 Apr 2015 ImClone completes a phase II trial in Urogenital cancer (combination therapy; second-line therapy or greater) in Canada and USA (NCT01282463)
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