Drug Profile


Alternative Names: RG-7090; RO-4917523

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Roche
  • Developer Chugai Pharmaceutical; Roche
  • Class Antidepressants; Fluorobenzenes; Imidazoles; Pyridines; Small molecules
  • Mechanism of Action Metabotropic glutamate receptor 5 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Major depressive disorder
  • Discontinued Fragile X syndrome

Most Recent Events

  • 17 Aug 2015 Phase-II development for treatment-resistant depression is ongoing in US, EU, Japan, Chile, Mexico, Russia and Taiwan
  • 01 Aug 2015 Roche completes a phase I trial for Major depressive disorder in USA (NCT02433093)
  • 10 Feb 2015 Discontinued - Phase-II for Fragile X syndrome (In adolescents, In adults) in USA, Argentina, Canada, Chile, France, Mexico, Peru, Spain, Sweden and United Kingdom (PO) before February 2015
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