Research programme: anticancer prodrugs - Threshold Pharmaceuticals

Drug Profile

Research programme: anticancer prodrugs - Threshold Pharmaceuticals

Alternative Names: HAP; Hypoxia-activated prodrug technology - Threshold; TH-3424

Latest Information Update: 22 Dec 2016

Price : $50

At a glance

  • Originator Threshold Pharmaceuticals
  • Developer National Cancer Institute (USA); Threshold Pharmaceuticals
  • Class Small molecules
  • Mechanism of Action AKR1C3 protein inhibitors; Alkylating agents; DNA cross linking agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Hepatocellular carcinoma; Solid tumours
  • Research Acute lymphoblastic leukaemia

Most Recent Events

  • 19 Dec 2016 Early research in Acute lymphoblastic leukaemia in Australia (unspecified route)
  • 29 Sep 2016 Threshold Pharmaceuticals plans a phase I trial for TH 3424 for Solid tumours in 2017
  • 25 Apr 2016 Preclinical trials in Hepatocellular carcinoma in USA (unspecified route)
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