Drug Profile


Alternative Names: esomeprazole magnesium trihydrate/naproxen; Naproxen/esomeprazole; naproxen/esomeprazole magnesium trihydrate; PN-400; Vimovo

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator AstraZeneca; POZEN
  • Developer Aralez Pharmaceuticals Inc.; AstraZeneca
  • Class 2 pyridinylmethylsulfinylbenzimidazoles; Anti-inflammatories; Naphthaleneacetic acids; Nonsteroidal anti-inflammatories; Small molecules
  • Mechanism of Action Cyclooxygenase inhibitors; Prostaglandin synthase inhibitors; Proton pump inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Marketed Ankylosing spondylitis; Osteoarthritis; Rheumatoid arthritis

Most Recent Events

  • 28 Jul 2017 Chemical structure information added
  • 27 Jun 2017 United States District Court for the District of New Jersey upholds validity of patent infringement lawsuit filed against Dr. Reddy's Laboratories, Lupin Pharmaceuticals, Mylan Pharmaceuticals and Mylan Laboratories by Horizon Pharma for infringing two Horizon Pharma patents covering naproxen/esomeprazole magnesium in USA
  • 30 Mar 2017 Horizon Pharma receives patent allowance from USPTO for naproxen/esomeprazole
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