Epacadostat

Drug Profile

Epacadostat

Alternative Names: INCB-024360; INCB-24360

Latest Information Update: 19 Jun 2017

Price : $50

At a glance

  • Originator Incyte Corporation
  • Developer Bristol-Myers Squibb; Immunovaccine; Incyte Corporation; MedImmune; Merck AG
  • Class Amides; Antineoplastics; Imides; Oxadiazoles; Small molecules
  • Mechanism of Action Indoleamine-pyrrole 2,3-dioxygenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Malignant melanoma
  • Phase II Fallopian tube cancer; Non-small cell lung cancer; Ovarian cancer; Peritoneal cancer; Solid tumours
  • Phase I/II Colorectal cancer; Glioblastoma; Head and neck cancer
  • Preclinical Pancreatic cancer

Most Recent Events

  • 07 Jun 2017 University of Pittsburgh, Incyte Corporation and Merck Sharp & Dohme plan a phase Ib/II trial for Colorectal cancer (Metastatic disease, Second-line therapy or greater, Combination therapy) (NCT03182894)
  • 05 Jun 2017 Updated adverse events and efficacy data from the phase I/II ECHO-204 trial in Head and Neck cancer, Malignant melanoma, Colorectal Cancer, Non small cell lung cancer, Ovarian Cancer, Lymphoma and Glioblastoma presented at the annual meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 05 Jun 2017 Adverse events data from the phase I/II KEYNOTE-037 study in Solid tumours presented at the 53rd Annual Meeting of the American Society for Clinical Oncology (ASCO-2017)
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