Axalimogene filolisbac

Drug Profile

Axalimogene filolisbac

Alternative Names: ADXS HPV; ADXS-11-001; AXAL; Cervical cancer vaccine - Advaxis; Head and neck cancer vaccine - Advaxis; Listeria cancer vaccine - Advaxis; Listeria monocytogenes vaccine live attenuated - Advaxis; Live attenuated listeria monocytogenes vaccine - Advaxis; Lm Technology™; Lm-Listeriolysin-O-fetal liver kinase-1; Lm-LLO-E7; Lm-LLO-E7 vaccine; Lovaxin-C

Latest Information Update: 18 Oct 2017

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At a glance

  • Originator Advaxis
  • Developer Advaxis; Brown University Medical School; Cancer Research UK; Gynecologic Oncology Group; Icahn School of Medicine at Mount Sinai; MedImmune
  • Class Cancer vaccines; Gene therapies
  • Mechanism of Action Human papillomavirus E7 protein inhibitors; Immunostimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Head and neck cancer; Anal cancer; Cervical cancer
  • New Molecular Entity No

Highest Development Phases

  • Phase III Cervical cancer
  • Phase II Anal cancer; Head and neck cancer; Oropharyngeal cancer
  • Discontinued Cervical intraepithelial neoplasia

Most Recent Events

  • 08 Sep 2017 Interim adverse events data from the phase II FAWCETT trial in Anal cancer presented at the 42nd European Society for Medical Oncology Congress (ESMO-2017)
  • 13 Jun 2017 Safety and efficacy results from the phase II FAWCETT trial in Anal cancer released by Advaxis
  • 15 May 2017 Advaxis plans a second phase III trial for Cervical cancer (Metastatic disease, Recurrent) in 2017
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