Varlilumab

Drug Profile

Varlilumab

Alternative Names: CDX-1127

Latest Information Update: 30 Dec 2016

Price : $50

At a glance

  • Originator Celldex Therapeutics Inc
  • Developer Celldex Therapeutics Inc; Oncothyreon; University of Virginia
  • Class Antigens; Antineoplastics; Monoclonal antibodies
  • Mechanism of Action CD27 antigen inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Malignant melanoma; Solid tumours
  • Phase I/II Renal cell carcinoma
  • Phase I Haematological malignancies; Prostate cancer
  • Discontinued Breast cancer; Ovarian cancer

Most Recent Events

  • 30 Nov 2016 Celldex Therapeutics terminates a pilot phase I trial in Prostate cancer (Combination therapy) in USA due to low accrual (NCT02284971)
  • 07 Nov 2016 Celldex Pharmaceuticals closed a phase I/II trial in Malignant melanoma (Combination therapy, Late-stage disease, Inoperable/Unresectable) in USA (IV) due to reluctance of physicians to use ipilimumab in this setting (NCT02413827)
  • 04 Oct 2016 University of California at San Francisco plans a pilot phase I trial for Glioma (Combination therapy, Second-line therapy or greater, Neoadjuvant therapy) in USA (IV) (NCT02924038)
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