Drug Profile


Alternative Names: CDX-1127

Latest Information Update: 23 Jun 2017

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At a glance

  • Originator Celldex Therapeutics Inc
  • Developer Celldex Therapeutics Inc; Oncothyreon; University of California at San Francisco; University of Virginia
  • Class Antigens; Antineoplastics; Monoclonal antibodies
  • Mechanism of Action CD27 antigen inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Malignant melanoma; Solid tumours
  • Phase I/II Renal cell carcinoma
  • Phase I Glioma; Haematological malignancies; Prostate cancer
  • Discontinued Breast cancer; Ovarian cancer

Most Recent Events

  • 18 Aug 2017 University Hospital Southampton NHS Foundation Trust and Cancer Research UK plans a phase II RiVa trial for Diffuse large B cell lymphoma, Follicular lymphoma, MALT lymphoma, Mantle cell lymphoma and Waldenstrom's macroglobulinaemia (Combination therapy, Metastatic disease, Late-stage disease, Second-line therapy or greater) in United Kingdom in August 2017 (ISRCTN15025004) (EudraCT2017-000302-37)
  • 05 Jun 2017 Interim efficacy and adverse events data from the phase I portion of the phase I/II trial in Solid tumours presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 15 Mar 2017 Celldex Therapeutics terminates a phase I/II trial for Solid tumours (Combination therapy, Late-stage disease) in USA due to portfolio re-prioritisation (NCT02543645)
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