Drug Profile


Alternative Names: CDX-1127

Latest Information Update: 04 Nov 2017

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At a glance

  • Originator Celldex Therapeutics Inc
  • Developer Celldex Therapeutics Inc; Oncothyreon; University of California at San Francisco; University of Virginia
  • Class Antigens; Antineoplastics; Monoclonal antibodies
  • Mechanism of Action CD27 antigen inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Malignant melanoma; Solid tumours
  • Phase I/II Renal cell carcinoma
  • Phase I Glioma; Prostate cancer
  • No development reported Haematological malignancies
  • Discontinued Breast cancer; Ovarian cancer

Most Recent Events

  • 04 Nov 2017 No recent reports of development identified for phase-I development in Haematological-malignancies in USA (IV)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Solid-tumours in USA (IV)
  • 18 Aug 2017 University Hospital Southampton NHS Foundation Trust and Cancer Research UK plans a phase II RiVa trial for Diffuse large B cell lymphoma, Follicular lymphoma, MALT lymphoma, Mantle cell lymphoma and Waldenstrom's macroglobulinaemia (Combination therapy, Metastatic disease, Late-stage disease, Second-line therapy or greater) in United Kingdom in August 2017 (ISRCTN15025004) (EudraCT2017-000302-37)
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