KW 2449

Drug Profile

KW 2449

Alternative Names: KW-2449

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Kyowa Pharmaceutical
  • Developer Kyowa Hakko Kirin; Kyowa Pharmaceutical
  • Class Antineoplastics; Indazoles; Piperazines; Small molecules
  • Mechanism of Action Aurora kinase inhibitors; Bcr-abl tyrosine kinase inhibitors; Fms-like tyrosine kinase 3 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Acute lymphoblastic leukaemia; Acute myeloid leukaemia; Chronic myeloid leukaemia; Myelodysplastic syndromes

Most Recent Events

  • 28 Jul 2010 Discontinued - Phase-I/II for Acute myeloid leukaemia in USA (PO)
  • 30 Mar 2010 Suspended - Phase-I/II for Acute myeloid leukaemia in USA (PO)
  • 11 Dec 2007 Interim efficacy, adverse events, pharmacodynamics and pharmacokinetics data from a Phase-I trial and a Preclinical trial in Cancer presented at the 49th Annual Meeting and Exposition of the American Society of Hematology (ASH-2007) ,
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