Research programme: autologous T cell therapies - TxCell

Drug Profile

Research programme: autologous T cell therapies - TxCell

Alternative Names: Ag-Treg therapeutics - TxCell; Balancell; CAR engineered CD4+ Treg cells - TxCell; CAR-Treg-TxCell; CellArthrix; Col-Treg-TxCell; ENTrIA; ENTX-BP; ENTX-LN; ENTX-MS; ENTX-SOT; HLA-A2 CAR-Treg - TxCell; HSP60-Treg-TxCell; Myelin-Treg-TxCell; Tr1 cell therapy - TxCell; TX-MSD

Latest Information Update: 29 Sep 2017

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At a glance

  • Originator Weizmann Institute of Science
  • Developer Ospedale San Raffaele; University of British Columbia; University of Lubeck; Weizmann Institute of Science
  • Class CAR-T cell therapies; Cell therapies
  • Mechanism of Action Immunosuppressants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Immune-mediated uveitis
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Bullous pemphigoid; Immune-mediated uveitis; Transplant rejection
  • Research Lupus nephritis
  • No development reported Autoimmune disorders

Most Recent Events

  • 26 Sep 2017 Pharmacodynamic results from a preclinical study in Transplant rejection presented at the18th Congress of the European Society for Organ Transplantation (ESOT-2017)
  • 19 Jun 2017 TxCell plans a first-in-man phase I trial for Transplant rejection in France and Canada by the end of 2018
  • 19 Jun 2017 TxCell and Lentigen Technology agree to manufacture HLA-A2 CAR lentiviral vector for the CAR-Treg product for Transplant rejection
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