Navitoclax

Drug Profile

Navitoclax

Alternative Names: ABT-263; RG 7423; RG 7433

Latest Information Update: 15 Nov 2017

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At a glance

  • Originator Abbott Laboratories
  • Developer Abbott Laboratories; AbbVie; Genentech
  • Class Antineoplastics; Benzamides; Morpholines; Piperazines; Small molecules; Sulfones
  • Mechanism of Action Apoptosis stimulants; Proto-oncogene protein c-bcl-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II Myelofibrosis
  • Discontinued Chronic lymphocytic leukaemia; Lymphoid leukaemia; Lymphoma; Non-small cell lung cancer; Small cell lung cancer; Solid tumours

Most Recent Events

  • 31 Oct 2017 Phase-II clinical trials in Myelofibrosis (Combination therapy, In adults, In the elderly, Second-line therapy or greater) in United Kingdom (PO) (NCT03222609)
  • 17 Jul 2017 AbbVie plans a phase II trial for Myelofibrosis (Combination therapy, In adults, In the elderly, Second-line therapy or greater) (PO) (NCT03222609)
  • 05 Jun 2017 AbbVie plans a phase I trial for Acute lymphoblastic leukaemia (In children, In adults, Combination therapy, Second-line therapy or greater) (PO) (NCT03181126)
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