Drug Profile


Alternative Names: Anti-PDGFRα mAb 3G3; IMC-3G3; Lartruvo; LY 3012207

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator ImClone Systems
  • Developer Eli Lilly
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Platelet derived growth factor alpha receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Soft tissue sarcoma
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Soft tissue sarcoma
  • Phase I/II Pancreatic cancer
  • Phase I Solid tumours
  • No development reported Gastrointestinal stromal tumours; Glioblastoma; Non-small cell lung cancer; Ovarian cancer; Prostate cancer

Most Recent Events

  • 20 Sep 2017 Eli Lilly plans a phase I trial for Soft tissue sarcoma (Late-stage disease, Metastatic disease, Combination therapy) (NCT03283696)
  • 05 Jul 2017 Phase-I clinical trials in Soft tissue sarcoma (Late-stage disease, Metastatic disease, Combination therapy, Second-line therapy or greater, Inoperable/Unresectable) in USA (IV) (NCT03126591)
  • 22 Jun 2017 Phase-I/II clinical trials in Pancreatic cancer (First-line therapy, Combination therapy, Metastatic disease) in USA, Germany (IV) (EudraCT2016-001099-31; NCT03086369)
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