ENMD 2076

Drug Profile

ENMD 2076

Alternative Names: ENMD-2076; ENMD-981693; MKC-1693

Latest Information Update: 18 Jul 2017

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At a glance

  • Originator Miikana Therapeutics
  • Developer CASI Pharmaceuticals
  • Class Antineoplastics; Piperazines; Pyrazoles; Pyrimidines; Small molecules
  • Mechanism of Action Angiogenesis inhibitors; Aurora kinase A inhibitors; Fms-like tyrosine kinase 3 inhibitors; Type 3 fibroblast growth factor receptor antagonists; Vascular endothelial growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer; Multiple myeloma; Hepatocellular carcinoma; Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Breast cancer; Hepatocellular carcinoma; Ovarian cancer; Soft tissue sarcoma
  • Phase I Acute myeloid leukaemia; Cancer; Haematological malignancies; Multiple myeloma

Most Recent Events

  • 30 Jun 2017 CASI Pharmaceuticals completes a phase II trial in triple-negative Breast Cancer (Second-line therapy or greater) in USA and China (NCT01639248)
  • 02 Jun 2017 Efficacy, pharmacodynamics and adverse events data from a phase II trial in Ovarian cancer presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 18 May 2017 Efficacy data from a phase II trial in Ovarian cancer (Second-line therapy or greater) released by CASI Pharmaceuticals
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