Rucaparib

Drug Profile

Rucaparib

Alternative Names: AG 014699; AG-14699; CO-338; PF-01367338; PF-1367338; Rubraca; Rucaparib camsylate

Latest Information Update: 03 Apr 2017

Price : $50

At a glance

  • Originator Cancer Research UK
  • Developer Cancer Research UK; Clovis Oncology; UNICANCER
  • Class 3-ring heterocyclic compounds; Antineoplastics; Azepines; Indoles; Small molecules
  • Mechanism of Action Poly(ADP-ribose) polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Ovarian cancer
  • Phase III Fallopian tube cancer; Peritoneal cancer; Prostate cancer
  • Phase II Breast cancer; Pancreatic cancer
  • Phase I Solid tumours
  • Suspended Malignant melanoma

Most Recent Events

  • 21 Apr 2017 Clovis and Roche plans a phase I trial for Ovarian cancer (Combination therapy, Second-line therapy or greater, Late-stage disease) in Australia and United Kingdom (NCT03101280)
  • 13 Mar 2017 Clovis Oncology completes enrolment in the ARIEL2 phase II trial for Ovarian cancer in USA, Australia, Canada, France, Spain and the UK
  • 22 Feb 2017 CHMP opinion expected on approval of rucaparib in Ovarian cancer in European Union
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