Rucaparib

Drug Profile

Rucaparib

Alternative Names: AG 014699; AG-14699; CO-338; PF-01367338; PF-1367338; RUBRACA; Rucaparib camsylate

Latest Information Update: 25 Mar 2017

Price : $50

At a glance

  • Originator Cancer Research UK
  • Developer Cancer Research UK; Clovis Oncology; UNICANCER
  • Class 3-ring heterocyclic compounds; Antineoplastics; Azepines; Indoles; Small molecules
  • Mechanism of Action Poly(ADP-ribose) polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Ovarian cancer
  • Phase III Fallopian tube cancer; Peritoneal cancer; Prostate cancer
  • Phase II Breast cancer; Pancreatic cancer
  • Phase I Solid tumours
  • Suspended Malignant melanoma

Most Recent Events

  • 22 Feb 2017 CHMP opinion expected on approval of rucaparib in Ovarian cancer in European Union
  • 22 Feb 2017 An investigator-sponsored phase II trial (PLATFORM) is planned for Gastric cancer and Oesophageal cancer (First-line treatment) in the first quarter of 2017 ; Clovis Oncology 10-K, February 2017)
  • 01 Jan 2017 Phase-III clinical trials in Prostate cancer (Hormone refractory, Metastatic disease, Second-line therapy or greater) in USA (PO) (NCT02975934)
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