Guadecitabine- Astex Pharmaceuticals

Drug Profile

Guadecitabine- Astex Pharmaceuticals

Alternative Names: Decitabine deoxyguanosine; Decitabine deoxyguanosine dinucleotide; S-110; SGI-110

Latest Information Update: 11 Sep 2017

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At a glance

  • Originator SuperGen
  • Developer Astex Pharmaceuticals; Columbia University; Genentech; John Hopkins University; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); Weill Cornell Medical College
  • Class Antineoplastics; Aza compounds; Deoxyribonucleosides; Furans; Purine nucleosides; Small molecules; Triazines
  • Mechanism of Action Antimetabolites; DNA cytosine 5 methyltransferase 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia; Chronic myelomonocytic leukaemia; Myelodysplastic syndromes
  • Phase II Gastrointestinal stromal tumours; Hepatocellular carcinoma; Myeloproliferative disorders; Ovarian cancer; Pheochromocytoma; Renal cell carcinoma; Solid tumours
  • Phase I/II Bladder cancer; Colorectal cancer
  • Phase I Malignant melanoma; Non-small cell lung cancer; Small cell lung cancer

Most Recent Events

  • 29 Aug 2017 University of Southern California in collaboration with National Cancer Institute plans a phase Ib trial of guadecitabine and durvalumab for Hepatocellular carcinoma, Pancreatic adenocarcinoma, and Cholangiocarcinoma/Gallbladder cancer (Late-stage disease, Combination therapy) in USA in September 2017 (NCT03257761)
  • 16 Aug 2017 Phase-II clinical trials in Gastrointestinal stromal tumours (In children, In adults, In adolescents, In the elderly, Inoperable/Unresectable, Recurrent) in USA (SC) (NCT03165721)
  • 16 Aug 2017 Phase-II clinical trials in Phaeochromocytoma (In children, In adults, In adolescents, In the elderly, Inoperable/Unresectable, Recurrent) in USA (SC) (NCT03165721)
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