Crizotinib

Drug Profile

Crizotinib

Alternative Names: PF-002341066; PF-02341066; PF-1066; PF-2341066; Xalkori

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Pfizer
  • Developer Astellas Pharma; Dana-Farber Cancer Institute; National Cancer Institute (USA); OxOnc Development; Pfizer; University of Milan Bicocca
  • Class Antineoplastics; Chlorobenzenes; Fluorobenzenes; Piperidines; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action Anaplastic lymphoma kinase inhibitors; Proto oncogene protein c met inhibitors; ROS1-protein-inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase II Bladder cancer; Non-Hodgkin's lymphoma; Renal cell carcinoma
  • Phase I Glioblastoma; Prostate cancer; Solid tumours

Most Recent Events

  • 28 Apr 2017 Pfizer plans a phase I pharmacokinetics trial in Healthy volunteers in USA (PO) (NCT03137134)
  • 24 Apr 2017 Children's Oncology Group plans a phase III trial for Neuroblastoma in USA (NCT03126916)
  • 23 Feb 2017 Pfizer has patent protection for crizotinib in European Union and Japan (Pfizer Form 10-K, February 2017)
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