Crizotinib - Pfizer

Drug Profile

Crizotinib - Pfizer

Alternative Names: PF-002341066; PF-02341066; PF-1066; PF-2341066; Xalkori

Latest Information Update: 17 Nov 2017

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At a glance

  • Originator Pfizer
  • Developer Astellas Pharma; Dana-Farber Cancer Institute; National Cancer Institute (USA); OxOnc Development; Pfizer; University of Milan Bicocca
  • Class Antineoplastics; Chlorobenzenes; Fluorobenzenes; Piperidines; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action Anaplastic lymphoma kinase inhibitors; Proto oncogene protein c met inhibitors; ROS1-protein-inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase II Bladder cancer; Non-Hodgkin's lymphoma; Renal cell carcinoma
  • Phase I Glioblastoma; Prostate cancer; Solid tumours

Most Recent Events

  • 14 Nov 2017 Health Canada approves crizotinib for treatment of Non-small cell lung cancer (Late-stage disease; Metastatic disease; Second-line therapy or greater, Monotherapy, ROS1-positive) in Canada
  • 07 Nov 2017 Crizotinib is still in phase I trials for Prostate-cancer in USA (NCT02207504)
  • 07 Nov 2017 Crizotinib is still in phase I trials for Solid-tumours in Italy, Russia, Taiwan, Japan, China, South Korea, USA (PO, Capsule) (NCT01121588)
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