Drug Profile


Alternative Names: CRx-191; Nortriptyline/mometasone

Latest Information Update: 29 Mar 2011

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At a glance

  • Originator CombinatoRx
  • Developer Zalicus
  • Class Anti-inflammatories; Dibenzocycloheptenes; Glucocorticoids; Pregnadienediols
  • Mechanism of Action Lipocortin synthesis agonists; Phospholipase A2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.


Highest Development Phases

  • Discontinued Psoriasis

Most Recent Events

  • 31 Dec 2010 Discontinued - Phase-II for Psoriasis in Germany (Topical)
  • 09 Sep 2010 CombinatoRx is now called Zalicus
  • 13 Mar 2008 Interim efficacy and adverse event data from a phase II trial in psorasis released by CombinatoRx
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