Drug Profile


Alternative Names: 4D11; ASKP 1240

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Kirin Brewery
  • Developer Astellas Pharma; Kyowa Hakko Kirin
  • Class Antipsoriatics; Monoclonal antibodies
  • Mechanism of Action CD40 antigen inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Focal segmental glomerulosclerosis; Renal transplant rejection
  • Phase I Transplant rejection
  • Discontinued Plaque psoriasis

Most Recent Events

  • 01 Dec 2016 Phase-II clinical trials in Focal segmental glomerulosclerosis (Prevention of recurrence) in USA (IV) (NCT02921789)
  • 30 Sep 2016 Astellas Pharma plans a phase II trial for Focal segmental glomerulosclerosis in USA (NCT02921789)
  • 10 Aug 2015 Phase-II development is ongoing for Transplant organ rejection (Prevention) in USA
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