Drug Profile


Alternative Names: Dexmecamylamine hydrochloride; NIH-11008; S(+)-mecamylamine; S-mecamylamine; TC-5214

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Targacept
  • Developer AstraZeneca; Targacept
  • Class Antidepressants; Norbornanes; Small molecules
  • Mechanism of Action Alpha3beta4 nicotinic receptor antagonists; Alpha4beta2 nicotinic receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Hypertension; Major depressive disorder; Overactive bladder; Resistant hypertension

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 28 Jul 2014 Discontinued - Phase-II for Overactive bladder in USA (PO)
  • 28 Jul 2014 Top-line efficacy data from a phase IIb trial in Overactive bladder released by Targacept
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