Pevonedistat

Drug Profile

Pevonedistat

Alternative Names: Captisol®-enabled pevonedistat; MLN-4924; TAK-924

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Millennium Pharmaceuticals
  • Developer Takeda Oncology
  • Class 2 ring heterocyclic compounds; Amines; Antineoplastics; Cyclopentanes; Indenes; Pyrimidines; Pyrroles; Small molecules; Sulfonic acids
  • Mechanism of Action NEDD 8 activating enzyme inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Acute myeloid leukaemia; Chronic myelomonocytic leukaemia; Myelodysplastic syndromes
  • No development reported Haematological malignancies
  • Discontinued Solid tumours

Most Recent Events

  • 04 Sep 2017 Millennium Pharmaceuticals plans a phase III trial for Myelodysplastic syndrome, Chronic myelomonocytic leukaemia and Acute myeloid leukaemia (In volunteers) (NCT03268954)
  • 07 Aug 2017 Vanderbilt-Ingram Cancer Center and National Cancer Institute plan a phase II trial for Myelodysplastic syndromes and Myeloproliferative disorders (Second-line therapy or greater, Combination therapy, Refractory metastatic disease, Late-stage disease) in USA (NCT03238248)
  • 26 Jul 2017 University of Michigan Cancer Center plans a phase II trial for Non-small cell lung cancer (Treatment-experienced, Late-stage disease) in USA (NCT03228186)
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