Drug Profile


Alternative Names: HPK-56; MP-470

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Montigen
  • Developer Astex Pharmaceuticals
  • Class Amides; Antineoplastics; Small molecules
  • Mechanism of Action DNA repair inhibitors; Fms-like tyrosine kinase 3 inhibitors; Platelet derived growth factor alpha receptor antagonists; Proto oncogene protein c met inhibitors; Proto oncogene protein c-kit inhibitors; Rad51 recombinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Discontinued Glioblastoma; Small cell lung cancer

Most Recent Events

  • 11 Oct 2013 Astex Pharmaceuticals has been acquired by Otsuka Pharmaceutical
  • 21 Sep 2012 Efficacy data from the phase II ESCAPE trial in Small cell lung cancer released by Astex Pharmaceuticals
  • 21 Sep 2012 Amuvatinib is available for licensing as of 21 Sep 2012.
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