Dinaciclib

Drug Profile

Dinaciclib

Alternative Names: MK-7965; PS-095760; SCH 727965; SCHOOL 727965

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Pharmacopeia
  • Developer Merck & Co; University of California at San Francisco
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Apoptosis stimulants; CDC2 protein kinase inhibitors; Cyclin dependent kinase 9 inhibitors; Cyclin-dependent kinase 2 inhibitors; Cyclin-dependent kinase 5 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Chronic lymphocytic leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Chronic lymphocytic leukaemia
  • Phase I Breast cancer; Haematological malignancies
  • No development reported Non-small cell lung cancer
  • Discontinued Leukaemia; Mantle-cell lymphoma

Most Recent Events

  • 27 Jan 2017 Merck terminates a phase III trial in Chronic lymphocytic leukaemia (Second-line therapy or greater) due to program prioritisation and some safety or efficacy issues in USA, Belgium, Italy, Poland, Czech Republic, Sweden, Finland, Hungary, Lithuania, Latvia, Estonia, Spain, Greece, Norway and Slovakia
  • 15 Mar 2016 Biomarkers information updated
  • 01 Mar 2016 Phase-I clinical trials in Haematological malignancies (Second-line therapy or greater) in USA (IV) (NCT02684617)
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