Drug Profile


Alternative Names: AS-703026; EMD-1036239; MSC 1936369; MSC 1936369B; MSC1936369A

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Santhera Pharmaceuticals
  • Developer Merck Serono; Sanofi
  • Class Amides; Aminopyridines; Antineoplastics; Small molecules
  • Mechanism of Action Apoptosis stimulants; MAP kinase kinase 1 inhibitors; MAP kinase kinase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Malignant melanoma
  • Discontinued Colorectal cancer; Haematological malignancies; Ovarian cancer; Pancreatic cancer; Solid tumours

Most Recent Events

  • 10 Dec 2016 Adverse events and efficacy data from a phase II trial in Malignant melanoma (First-line therapy, Late-stage disease, Metastatic disease) presented at the 41st European Society for Medical Oncology Congress (ESMO-2016)
  • 24 Aug 2016 EMD Serono terminates a phase-I/II clinical trial in Colorectal cancer (Second-line or greater therapy, Combination therapy, Metastatic disease) in Spain, Belgium and Italy (PO) (NCT01085331)
  • 15 Mar 2016 Biomarkers information updated
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