CVA 21

Drug Profile

CVA 21

Alternative Names: Cavatak; Coxsackievirus A21; CVA21

Latest Information Update: 22 Nov 2017

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At a glance

  • Originator ViroTarg
  • Developer Merck & Co; Olivia Newton-John Cancer Research Institute; Viralytics
  • Class Antineoplastics; Oncolytic viruses
  • Mechanism of Action CD55 antigen inhibitors; Cell death stimulants; Intercellular adhesion molecule 1 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant melanoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Malignant melanoma
  • Phase I Bladder cancer; Lung cancer; Non-small cell lung cancer; Prostate cancer
  • Suspended Head and neck cancer
  • No development reported Breast cancer; Chronic lymphocytic leukaemia; Glioma; Mesothelioma; Multiple myeloma; Pancreatic cancer

Most Recent Events

  • 22 Nov 2017 Phase-I development is underway in Bladder-cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in United Kingdom and USA, in Lung-cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in United Kingdom, USA, in Bladder-cancer (Late-stage disease, Metastatic disease, Monotherapy, Second-line therapy or greater) in United Kingdom, in Lung-cancer (Late-stage disease, Metastatic disease, Monotherapy, Second-line therapy or greater) in United Kingdom, in Malignant-melanoma (Late-stage disease, Metastatic disease, Monotherapy, Second-line therapy or greater) in United Kingdom, in Prostate-cancer (Late-stage disease, Metastatic disease, Monotherapy, Second-line therapy or greater) in United Kingdom (IV, Infusion) (NCT02043665)
  • 13 Nov 2017 Viralytics plans a phase Ib trial in Colorectal cancer (Combination therapy with a checkpoint inhibitor, Metastatic disease to the liver) in USA
  • 13 Nov 2017 Viralytics plans the phase Ib CLEVER trial in Uveal melanoma (Combination therapy with ipilimumab, Metastatic disease to the liver) in USA (IV)
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