Drug Profile


Alternative Names: ASP-7487; OSI-906; OSI-906AA

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator OSI Pharmaceuticals
  • Developer Astellas Pharma; Multiple Myeloma Research Foundation
  • Class Cyclobutanes; Imidazoles; Pyrazines; Quinolines; Small molecules
  • Mechanism of Action Insulin receptor antagonists; Insulin-like growth factor-I receptor antagonists; Protein tyrosine kinase inhibitors; Receptor protein-tyrosine kinase antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Adrenocortical carcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • No development reported Multiple myeloma
  • Discontinued Adrenocortical carcinoma; Hepatocellular carcinoma; Non-small cell lung cancer; Ovarian cancer

Most Recent Events

  • 08 Aug 2016 No development reported - Phase-I/II for Multiple myeloma (Combination therapy, Second-line therapy or greater) in Canada, USA (PO)
  • 15 Mar 2016 Biomarkers information updated
  • 12 May 2014 Discontinued - Phase-II for Ovarian cancer in USA, Canada, Switzerland, United Kingdom, Australia, Italy, Poland, Romania and Russia (PO)
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