L19-IL2 fusion protein

Drug Profile

L19-IL2 fusion protein

Alternative Names: Anti-EDB-IL2 antibody conjugate; Anti-EDB-interleukin-2 antibody conjugate; Darleukin; Immunocytokine therapy; L19 interleukin-2 fusion-protein; L19-IL-2

Latest Information Update: 15 Dec 2016

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At a glance

  • Originator Philogen
  • Developer Bayer Schering Pharma; Maastricht Radiation Oncology; Philogen
  • Class Antineoplastics; Cytokines; Monoclonal antibodies; Recombinant fusion proteins
  • Mechanism of Action Angiogenesis inhibitors; Immunostimulants; Interleukin-2 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Malignant melanoma
  • Phase I/II Diffuse large B cell lymphoma; Pancreatic cancer
  • Phase I Head and neck cancer; Solid tumours
  • No development reported Renal cell carcinoma
  • Discontinued Atherosclerosis

Most Recent Events

  • 21 Jan 2016 Phase-III clinical trials in Malignant melanoma (Combination therapy, Metastatic disease) in Germany (IV)
  • 21 Jan 2016 Phase-III clinical trials in Malignant melanoma (Combination therapy, Metastatic disease) in Italy (IV)
  • 21 Jan 2016 Efficacy data from a phase II trial in Malignant melanoma released by Philogen
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