L19 TNF fusion protein - Philogen

Drug Profile

L19 TNF fusion protein - Philogen

Alternative Names: Fibromun; L19-TNF; L19TNFalpha

Latest Information Update: 14 Aug 2017

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At a glance

  • Originator Philogen
  • Class Antineoplastics; Monoclonal antibodies; Recombinant fusion proteins; Tumour necrosis factors
  • Mechanism of Action Angiogenesis inhibitors; Immunostimulants; Tumour necrosis factor stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Soft tissue sarcoma
  • New Molecular Entity No

Highest Development Phases

  • Phase III Soft tissue sarcoma
  • Phase II Malignant melanoma; Sarcoma
  • Phase I Breast cancer; Solid tumours
  • No development reported Colorectal cancer

Most Recent Events

  • 28 Jul 2017 Phase-III clinical trials in Soft tissue sarcoma (First-line therapy, Combination therapy, Metastatic disease, Late-stage disease) in Germany (IV) (EudraCT2016-003239-38)
  • 28 Oct 2016 L19 TNF fusion protein - Philogen receives Orphan Drug status for Soft tissue sarcoma in European Union
  • 21 Jan 2016 Efficacy data from a phase II trial in Malignant melanoma released by Philogen
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