Drug Profile


Alternative Names: E2MATE; Estradiol sulfamate; Estradiol-3-O-sulfamate; J 995 - PregLem; J-995; PGL-2001; ZK-190628

Latest Information Update: 17 Jun 2015

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At a glance

  • Originator Jenapharm
  • Developer PregLem
  • Class Estradiol congeners
  • Mechanism of Action Steryl sulfatase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Endometriosis

Most Recent Events

  • 17 Jun 2015 PGL 2 (PGL2001) is still in phase-IIa development for Endometriosis in Europe
  • 01 May 2014 PregLem completes the phase II AMBER trial in Endometriosis (Combination therapy) in Hungary, Poland and Germany (NCT01631981)
  • 17 May 2013 PregLem completes enrolment in the phase II AMBER trial for Endometriosis in Hungary, Poland & Romania (NCT01631981)
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