Drug Profile


Alternative Names: ASP 9785; MDV 3100; Xtandi

Latest Information Update: 12 Sep 2017

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At a glance

  • Originator University of California at Los Angeles; University of Texas M. D. Anderson Cancer Center
  • Developer Astellas Pharma; H. Lee Moffitt Cancer Center and Research Institute; M. D. Anderson Cancer Center; Medivation; National Cancer Institute (USA); Queen Mary University of London; The Prostate Cancer Clinical Trials Consortium; University of California, Davis; University of Chicago
  • Class Antineoplastics; Benzamides; Fluorobenzenes; Imidazolidines; Nitriles; Small molecules; Thiones
  • Mechanism of Action Androgen receptor antagonists; Apoptosis stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Prostate cancer
  • Phase II Endometrial cancer; Hepatocellular carcinoma; Salivary gland cancer
  • Phase I Pancreatic cancer
  • Discontinued Breast cancer

Most Recent Events

  • 21 Aug 2017 Astellas Pharma and Medivation initiates enrolment in a phase II trial in Prostate cancer (Combination therapy, Hormone refractory, Metastatic disease) in USA (NCT03246347)
  • 31 Jul 2017 Discontinued - Phase-II for Breast cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in Canada, USA, Germany, Spain, Italy and United Kingdom (PO) (Astellas Pipeline, July 2017)
  • 31 Jul 2017 Discontinued - Phase-II for Breast cancer (Combination therapy, Neoadjuvant therapy) in USA (PO) (Astellas Pipeline, July 2017)
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