Ruxolitinib

Drug Profile

Ruxolitinib

Alternative Names: INC-424; INCB 018424 phosphate; INCB-018424; INCB-18424; Jakafi; Jakavi; ruxolitinib phosphate

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Incyte Corporation
  • Developer Dana-Farber Cancer Institute; H. Lee Moffitt Cancer Center and Research Institute; Incyte Corporation; Lymphoma Academic Research Organisation; Novartis; RWTH Aachen University; Sunnybrook Health Sciences Centre; Tufts-New England Medical Center; University Health Network of Toronto; University of Cologne; University of Texas M. D. Anderson Cancer Center
  • Class 2 ring heterocyclic compounds; Antineoplastics; Antipsoriatics; Antirheumatics; Cyclopentanes; Nitriles; Pyrazoles; Pyrimidines; Pyrroles; Small molecules
  • Mechanism of Action Janus kinase 1 inhibitors; Janus kinase-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelofibrosis; Pancreatic cancer; Polycythaemia vera; Essential thrombocythaemia; Graft-versus-host disease
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Myelofibrosis; Polycythaemia vera
  • Phase III Essential thrombocythaemia; Graft-versus-host disease
  • Phase II Acute lymphoblastic leukaemia; Alopecia areata; Atopic dermatitis; Breast cancer; Chronic lymphocytic leukaemia; Chronic myelomonocytic leukaemia; Haematological malignancies; Hodgkin's disease; Myelodysplastic syndromes; Thalassaemia; Vitiligo
  • Phase I/II Acute myeloid leukaemia; Chronic myeloid leukaemia
  • No development reported Psoriasis
  • Discontinued Colorectal cancer; Multiple myeloma; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer; Rheumatoid arthritis

Most Recent Events

  • 10 Aug 2017 Phase-I clinical trials in Atopic dermatitis (In children) in USA (Topical) (NCT03257644)
  • 10 Jul 2017 Incyte Corporation terminates a phase II trial as other related studies of ruxolitinib did not provide sufficient efficacy to warrant continuation in Breast cancer (Combination therapy, Late-stage disease, Second-line therapy or greater, Metastatic disease) in United Kingdom, Spain, Portugal, Italy, France (PO) (NCT02120417)
  • 25 Jun 2017 Long term safety and efficacy data from the phase IIIb RESPONSE-2 trial in Polycythaemia vera presented at the 22nd Congress of the European Haematology Association (EHA-2017)
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