Ruxolitinib

Drug Profile

Ruxolitinib

Alternative Names: INC-424; INCB-018424; INCB-18424; Jakafi; Jakavi

Latest Information Update: 09 Jan 2017

Price : $50

At a glance

  • Originator Incyte Corporation
  • Developer H. Lee Moffitt Cancer Center and Research Institute; Incyte Corporation; Lymphoma Academic Research Organisation; Novartis; RWTH Aachen University; Sunnybrook Health Sciences Centre; University Health Network of Toronto; University of Cologne; University of Texas M. D. Anderson Cancer Center
  • Class 2 ring heterocyclic compounds; Antineoplastics; Antipsoriatics; Antirheumatics; Cyclopentanes; Nitriles; Pyrazoles; Pyrimidines; Pyrroles; Small molecules
  • Mechanism of Action Janus kinase 1 inhibitors; Janus kinase-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelofibrosis; Pancreatic cancer; Polycythaemia vera; Essential thrombocythaemia; Graft-versus-host disease
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    Polycythaemia vera
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Myelofibrosis; Polycythaemia vera
  • Phase III Essential thrombocythaemia
  • Phase II Acute lymphoblastic leukaemia; Alopecia areata; Atopic dermatitis; Chronic lymphocytic leukaemia; Chronic myelomonocytic leukaemia; Haematological malignancies; Hodgkin's disease; Myelodysplastic syndromes; Thalassaemia
  • Phase I/II Acute myeloid leukaemia; Chronic myeloid leukaemia
  • Clinical Phase Unknown Graft-versus-host disease
  • No development reported Psoriasis
  • Discontinued Breast cancer; Colorectal cancer; Multiple myeloma; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer; Rheumatoid arthritis

Most Recent Events

  • 30 Dec 2016 Ruxolitinib receives Orphan Drug status for Graft-versus-host disease in USA before December 2016
  • 30 Dec 2016 Incyte Corporation and Novartis plan pivotal trials for graft-versus-host disease
  • 04 Dec 2016 Pooled analysis of efficacy data from the phase III COMFORT I and COMFORT II trials in Myelofibrosis released by Incyte Corporation
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