Ruxolitinib - Incyte Corporation

Drug Profile

Ruxolitinib - Incyte Corporation

Alternative Names: INC-424; INCB 018424 phosphate; INCB-018424; INCB-18424; Jakafi; Jakavi; ruxolitinib phosphate

Latest Information Update: 17 Nov 2017

Price : *
* Final gross price and currency may vary according to local VAT and billing address.

At a glance

  • Originator Incyte Corporation
  • Developer Dana-Farber Cancer Institute; H. Lee Moffitt Cancer Center and Research Institute; Incyte Corporation; Lymphoma Academic Research Organisation; Novartis; RWTH Aachen University; Sunnybrook Health Sciences Centre; Tufts-New England Medical Center; University Health Network of Toronto; University of Cologne; University of Texas M. D. Anderson Cancer Center
  • Class 2 ring heterocyclic compounds; Antineoplastics; Antipsoriatics; Antirheumatics; Cyclopentanes; Nitriles; Pyrazoles; Pyrimidines; Pyrroles; Small molecules
  • Mechanism of Action Janus kinase 1 inhibitors; Janus kinase-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelofibrosis; Pancreatic cancer; Polycythaemia vera; Essential thrombocythaemia; Graft-versus-host disease
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Myelofibrosis; Polycythaemia vera
  • Phase III Essential thrombocythaemia; Graft-versus-host disease
  • Phase II Acute lymphoblastic leukaemia; Alopecia areata; Atopic dermatitis; Breast cancer; Chronic lymphocytic leukaemia; Chronic myelomonocytic leukaemia; Haematological malignancies; Hodgkin's disease; Myelodysplastic syndromes; Thalassaemia; Vitiligo
  • Phase I/II Acute myeloid leukaemia; Chronic myeloid leukaemia
  • No development reported Psoriasis
  • Discontinued Colorectal cancer; Multiple myeloma; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer; Rheumatoid arthritis

Most Recent Events

  • 17 Nov 2017 Phase-I development is ongoing in Chronic-myeloid-leukaemia(Combination therapy) in USA (PO, Tablet) (NCT01702064)
  • 17 Nov 2017 Phase-I development is underway in Myelofibrosis (Combination therapy) in Israel, Austria, Australia, Singapore, Spain, Italy, Ireland, Germany, France, United Kingdom (PO, Tablet) (NCT01433445; NCT01730248)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Myelofibrosis(Combination therapy) in Israel, Austria, Australia, Singapore, Spain, Italy, Ireland, Germany, France, United Kingdom (PO, Tablet)
Restricted Access

Oops, it looks like you don’t have a valid subscription to this content. To gain full access to the content and functionality of the AdisInsight database try one of the following.

  • with a username/password associated to an account with a valid subscription
  • Contact your organization’s admin about adding this content to your AdisInsight subscription
  • Request a trial

If you are a subscriber to this content then contact us at AsktheExpert.AdisInsight@springer.com so we can help.

Back to top