Evofosfamide

Drug Profile

Evofosfamide

Alternative Names: HAP 302; TH-302

Latest Information Update: 04 Apr 2017

Price : $50

At a glance

  • Originator Threshold Pharmaceuticals; University of Texas M. D. Anderson Cancer Center
  • Developer Grupo Espanol de Tumores Neuroendocrinos; Merck KGaA; Scripps Clinic; Threshold Pharmaceuticals; University of Texas Health Science Center at San Antonio; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Nitroimidazoles; Phosphoramide mustards; Small molecules
  • Mechanism of Action Alkylating agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Soft tissue sarcoma; Pancreatic cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Biliary cancer; Glioblastoma; Pancreatic cancer
  • Phase I Hepatocellular carcinoma
  • Phase Unknown Solid tumours
  • Suspended Leukaemia; Malignant melanoma; Multiple myeloma; Non-small cell lung cancer
  • Discontinued Soft tissue sarcoma

Most Recent Events

  • 27 Mar 2017 Phase-I clinical trials in Hepatocellular carcinoma (Inoperable/Unresectable, Combination therapy) in USA before March 2017 (Intra-arterial)
  • 25 Jan 2017 Investigation in Solid tumours (Combination therapy) in USA (IV)
  • 25 Jan 2017 Phase-II clinical trials in Glioblastoma (Combination therapy, Second-line therapy or greater) in USA (IV)
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