Drug Profile


Alternative Names: BI-6727

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Boehringer Ingelheim
  • Class Amides; Antineoplastics; Piperazines; Pteridines; Small molecules
  • Mechanism of Action Polo-like kinase 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia
  • Phase II Myelodysplastic syndromes; Non-small cell lung cancer; Ovarian cancer
  • Phase I Chronic myelomonocytic leukaemia; Solid tumours
  • No development reported Urogenital cancer

Most Recent Events

  • 15 Feb 2017 Boehringer Ingelheim and Massachusetts General Hospital withdraw prior to enrolment a phase I trial for Acute myeloid leukaemia (Combination therapy) in USA (NCT02905994)
  • 26 Jan 2017 Boehringer Ingelheim withdrew phase I trial prior to enrolment in Acute myeloid leukaemia in Belgium, Denmark, Czech Republic and Netherlands (NCT02722135)
  • 10 Jan 2017 Boehringer Ingelheim terminates phase I trial for Myelodysplastic syndromes or Chronic myelomonocytic leukaemia in Germany and France (IV) (NCT01957644)
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