Drug Profile


Alternative Names: AR-119; BAY-86-9766; RDEA-119; VRX-119

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Valeant Pharmaceuticals International
  • Developer Ardea Biosciences; Bayer HealthCare; Samsung Medical Center
  • Class Aniline compounds; Anti-inflammatories; Antineoplastics; Small molecules; Sulfonamides
  • Mechanism of Action Mitogen-activated protein kinase kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Biliary cancer; Hepatocellular carcinoma
  • Phase I/II Pancreatic cancer; Solid tumours
  • Discontinued Inflammation

Most Recent Events

  • 08 Feb 2017 Bayer completes a phase II trial in hepatocellular carcinoma (Combination therapy, First-line therapy, Inoperable/Unresectable, Metastatic disease) in USA, Austria, Belgium, Czech Republic, France, Germany, Hungary, Italy, Spain, United Kingdom, Hong Kong, Israel, South Korea, Singapore, Turkey, Taiwan, Thailand, China, Japan, New Zealand, Switzerland (NCT01915602)
  • 13 Oct 2016 Samsung Medical Center completes a phase II trial in Biliary cancer (Second-line therapy or greater, Metastatic disease, Inoperable/Unresectable) in South Korea (PO) (NCT02346032)
  • 29 Apr 2016 Biomarkers information updated
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