Irinotecan sucrosofate - Ipsen

Drug Profile

Irinotecan sucrosofate - Ipsen

Alternative Names: Irinotecan liposome injection - Merrimack; MM-398; nal-IRI; Nano-irinotecan; Nanoliposomal irinotecan - Merrimack/PharmaEngine; Nanoliposomal irinotecan injection - Merrimack/PharmaEngine; Onivyde; pegylated liposomal irinotecan hydrochloride trihydrate; PEP-02

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator HERMES BioSciences
  • Developer Medica Scientia Innovation Research; Merrimack Pharmaceuticals; PharmaEngine; Shire; University of California at San Francisco
  • Class Alkaloids; Antineoplastics; Camptothecins; Small molecules
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer
  • New Molecular Entity No

Highest Development Phases

  • Marketed Pancreatic cancer
  • Phase II Breast cancer; Colorectal cancer; Gastric cancer
  • Phase I Glioma; Solid tumours
  • Phase Unknown Cholangiocarcinoma; Gallbladder cancer

Most Recent Events

  • 11 Aug 2017 Registered for Pancreatic cancer (Combination therapy, Metastatic disease, Second-line therapy or greater) in Canada (IV)
  • 06 Apr 2017 Merrimack Pharmaceuticals, Rhode Island Hospital and Brown University plan the phase I/II BrUOG 329 trial for Glioblastoma (Combination therapy, Second-line therapy or greater, Recurrent) in USA (NCT03119064)
  • 03 Apr 2017 Ipsen acquires irinotecan sucrosofate from Merrimack Phamaceuticals
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