Irinotecan sucrosofate - Merrimack/PharmaEngine

Drug Profile

Irinotecan sucrosofate - Merrimack/PharmaEngine

Alternative Names: Irinotecan liposome injection - Merrimack; MM-398; nal-IRI; Nano-irinotecan; Nanoliposomal irinotecan - Merrimack/PharmaEngine; Nanoliposomal irinotecan injection - Merrimack/PharmaEngine; Onivyde; pegylated liposomal irinotecan hydrochloride trihydrate; PEP-02

Latest Information Update: 15 Feb 2017

Price : $50

At a glance

  • Originator HERMES BioSciences
  • Developer Merrimack Pharmaceuticals; PharmaEngine; Shire; University of California at San Francisco
  • Class Alkaloids; Antineoplastics; Camptothecins; Small molecules
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

  • New Molecular Entity No

Highest Development Phases

  • Marketed Pancreatic cancer
  • Phase II Colorectal cancer; Gastric cancer
  • Phase I Glioma; Solid tumours
  • Phase Unknown Cholangiocarcinoma; Gallbladder cancer

Most Recent Events

  • 13 Feb 2017 AIO-Studien-ggGmbH, Baxalta, Institut für Klinisch-Onkologische Forschung (IKF) am Krankenhaus Nordwest GmbH and Shire plan a phase II trial for Biliary tract cancer (NCT03044587)
  • 03 Feb 2017 AIO-Studien-gGmbH, Baxalta and Shire plan the phase II NALIRICC trial for Cholangiocarcinoma and Gallbladder cancer (Second-line therapy or greater, Combination therapy, Late-stage disease, Metastatic disease, Inoperable/Unresectable) in Germany (IV) (NCT03043547)
  • 26 Jan 2017 Investigation in Cholangiocarcinoma in Germany (IV) before January 2017
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