Drug Profile


Alternative Names: Alpha-7 nAChR; EVP-6124; MT-4666

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Bayer HealthCare
  • Developer Bayer HealthCare; FORUM Pharmaceuticals; Mitsubishi Tanabe Pharma Corporation
  • Class 2 ring heterocyclic compounds; Amides; Azabicyclo compounds; Nootropics; Quinuclidines; Thiophenes
  • Mechanism of Action Alpha7 nicotinic acetylcholine receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Alzheimer's disease; Cognition disorders

Most Recent Events

  • 02 Aug 2016 Encenicline is no longer licensed to Mitsubishi Tanabe in Japan (Mitsubishi Tanabe pipeline, August 2016)
  • 02 Aug 2016 Discontinued - Phase-II for Alzheimer's disease in Japan (PO) (Mitsubishi Tanabe pipeline, August 2016)
  • 01 May 2016 FORUM terminates phase III trial in Cognition disorders (Adjunctive treatment) in USA, Canada, Mexico, United Kingdom, France, the Czech Republic, the Netherlands, Germany, Italy, Spain, South Korea, South Africa and Australia (NCT01969136)
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