Research programme: S-nitrosothiol modulating agents - Alpine Immune Therapeutics

Drug Profile

Research programme: S-nitrosothiol modulating agents - Alpine Immune Therapeutics

Alternative Names: GSNORi's - Alpine Immune Sciences; N 6547; N 91121; N 91138; N 91169; N6022 analogues; S nitrosoglutathione reductase inhibitors - Alpine Immune Sciences

Latest Information Update: 26 Jul 2017

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At a glance

  • Originator NitroMed
  • Developer Alpine Immune Sciences
  • Class Small molecules
  • Mechanism of Action Cystic fibrosis transmembrane conductance regulator modulators; Glutathione-independent formaldehyde dehydrogenase inhibitors; Nitric oxide stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Chronic obstructive pulmonary disease; Cystic fibrosis; Inflammatory bowel diseases; Respiratory tract disorders

Most Recent Events

  • 25 Jul 2017 Alpine Immune Sciences merged with Nivalis Therapeutics forming Alpine Immune Sciences
  • 23 Dec 2013 N30 Pharmaceuticals plans a phase I trial in Healthy volunteers in the USA (SNO2; NCT02013388)
  • 21 Mar 2013 Preclinical pharmacodynamics data from studies in Cystic fibrosis and Chronic obstructive pulmonary disease released by N30 Pharma
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